MED14 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-16945

Overview

Synonyms Activator-recruited cofactor 150 kDa component,ARC150,Cofactor required for Sp1 transcriptional activation subunit 2,CRSP complex subunit 2,DRIP150,EXLM1,hRGR1,MED14,MED14,Mediator complex subunit 14,Mediator of RNA polymerase II transcription subunit 14,RGR1,RGR1 homolog,Thyroid hormone receptor-associated protein complex 170 kDa component,Transcriptional coactivator CRSP150,Trap170,Vitamin D3 receptor-interacting protein complex 150 kDa component
Swissprot O60244
Source Rabbit
Reactivity Human
Immunogen Synthetic peptide of human MED14
Application IHC,ELISA
Recommended dilution IHC 1:25-1:100
Concentration 0.3mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.

 

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