MEF2A Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-32001

Overview

Synonyms ADCAD1,MADS box transcription enhancer factor 2,polypeptide A (myocyte enhancer factor 2A),MEF2,MEF2A,MEF2A,Myocyte enhancer factor 2A,Myocyte-specific enhancer factor 2A,RSRFC4,RSRFC9,Serum response factor like protein 1,Serum response factor-like protein 1
Swissprot Q02078
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from human MEF-2 around the non-phosphorylation site of Ser408.
Application WB,IHC-p,IF,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.

 

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