MOB1B Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-32062

Overview

Synonyms MATS 2,MATS2,MGC33910,Mob 1A,Mob 1B,MOB 4A,MOB kinase activator 1B,Mob1 homolog 1A,MOB1 Mps One Binder homolog B,MOB1 Mps one binder kinase activator like 1A,Mob1A,Mob1B,MOBKL 1A,MOBKL1A,MOL1A,Mps one binder kinase activator like 1A,Mps one binder kinase activator-like 1A,Protein Mob4A
Swissprot Q7L9L4
Source Rabbit
Reactivity Human,Mouse,Monkey
Immunogen Synthesized peptide derived from the Internal region of human Mob1A
Application WB,IHC-p,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

 

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