MSH2 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-60195

Overview

Synonyms BAT26,COCA 1,COCA1,DNA mismatch repair protein Msh2,FCC 1,FCC1,hMSH2,HNPCC 1,HNPCC,HNPCC1,LCFS2,MSH 2,Msh2,MSH2,MutS homolog 2,MutS homolog 2 colon cancer nonpolyposis type 1,MutS protein homolog 2
Swissprot P43246
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human MSH2
Application WB,IP
Recommended dilution WB 1:500 - 1:2000 IP 1:20 - 1:50
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

 

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