MTOR Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-70304

Overview

Synonyms dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1),FK506 binding protein 12 rapamycin associated protein 1,FK506 binding protein 12 rapamycin associated protein 2,FK506 binding protein 12 rapamycin complex associated protein 1,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP rapamycin associated protein,FKBP12 rapamycin complex associated protein,FKBP12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,FLJ44809,FRAP,FRAP1,FRAP2,Mammalian target of rapamycin,Mechanistic target of rapamycin,mTOR,MTOR,OTTHUMP00000001983,RAFT1,Rapamycin and FKBP12 target 1,Rapamycin associated protein FRAP2,Rapamycin target protein 1,Rapamycin target protein,RAPT1,Serine/threonine-protein kinase mTOR
Swissprot P42345,Q9JLN9,P42346
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein corresponding to Mouse mTOR
Application WB
Recommended dilution WB 1:1000
Concentration 0.8 mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
Background MTOR, also named as FRAP1, FRAP, FRAP2 and RAPT1, belongs to the PI3/PI4-kinase family. MTOR is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. MTOR is Kinase subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. The antibody is specific to MTOR.

 

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