NCOA2 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-63329

Overview

Synonyms bHLHe75,Class E basic helix-loop-helix protein 75,glucocorticoid receptor interacting protein 1,GRIP 1,GRIP1,hTIF2,MED1,MGC138808,NCoA 2,NCoA-2,Ncoa2,NCOA2,Nuclear receptor coactivator 2,Oncogene FGR,p160,SRC 2,src2,Steroid receptor coactivator 2,TIF 2,TIF2,Transcriptional intermediary factor 2
Swissprot Q15596
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human NCOA2
Application WB,IHC
Recommended dilution WB 1:500 - 1:2000 IHC 1:50 - 1:200
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.

 

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