NMBR Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-32256

Overview

Synonyms Neuromedin B preferring bombesin receptor,Neuromedin B receptor,Neuromedin-B receptor,Neuromedin-B-preferring bombesin receptor,NMB R,NMB-R,Nmbr,NMBR
Swissprot P28336
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the Internal region of human NMBR
Application WB,IF,ELISA
Recommended dilution WB 1:500-1:2000, IF 1:200-1:1000, ELISA 1:5000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. NMBR (Neuromedin B Receptor) is a Protein Coding gene. Diseases associated with NMBR include Lung Cancer and Small Cell Cancer Of The Lung, Somatic. Among its related pathways are Peptide ligand-binding receptors and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and bombesin receptor activity. An important paralog of this gene is GRPR.

 

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