NUDT1 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64559

Overview

Synonyms 2-hydroxy-dATP diphosphatase,7 8 dihydro 8 oxoguanine triphosphatase,7,8 oxo 7 8 dihydrodeoxyguanosine triphosphatase,8 oxo 7 8 dihydroguanosine triphosphatase,8 oxo dGTPase,8-dihydro-8-oxoguanine triphosphatase,8-oxo-dGTPase,8ODP,MTH 1,MTH1,MutT human homolog 1,Nucleoside diphosphate linked moiety X motif 1,Nucleoside diphosphate linked moiety X type motif 1,Nucleoside diphosphate-linked moiety X motif 1,Nudix (nucleoside diphosphate linked moiety X) type motif 1,Nudix hydrolase 1,Nudix motif 1,Nudix type motif 1,NUDT 1,Nudt1
Swissprot P36639
Source Rabbit
Reactivity Human
Immunogen Recombinant protein of human NUDT1
Application WB,IHC,IP
Recommended dilution WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:20 - 1:50
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

 

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