NUDT15 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64940

Overview

Synonyms 8-dihydro-8-oxoguanine triphosphatase NUDT15,8-oxo-dGTPase NUDT15,A730068G11Rik,EC 3.1.6.-,FLJ10956,MGC104352,MTH2,MutT homolog 2,Nucleoside diphosphate-linked moiety X motif 15,NUD15,Nudix (nucleoside diphosphate linked moiety X)-type motif ,Nudix motif 15,NUDT15,OTTHUMP00000018389,Probable 7,Probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15,RP11-90M2.1
Swissprot Q9NV35
Source Rabbit
Reactivity Mouse,Rat
Immunogen Recombinant protein of human NUDT15
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.

 

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