OGDH Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64195

Overview

Synonyms 2 oxoglutarate dehydrogenase,2 oxoglutarate dehydrogenase complex component E1,2 oxoglutarate dehydrogenase mitochondrial,2-oxoglutarate dehydrogenase,2-oxoglutarate dehydrogenase complex component E1,AKGDH,Alpha ketoglutarate dehydrogenase,Alpha-ketoglutarate dehydrogenase,E1k,mitochondrial,ODO1,OGDC,OGDC E1,OGDC-E1,OGDH,Oxoglutarate (alpha ketoglutarate) dehydrogenase (lipoamide),Oxoglutarate decarboxylase,Oxoglutarate dehydrogenase (lipoamide),Oxoglutarate dehydrogenase (succinyl transferring)
Swissprot Q02218
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human OGDH
Application WB,IHC,IF
Recommended dilution WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

 

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