OPRK1 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64902

Overview

Synonyms K-OR-1,Kappa opioid receptor,Kappa type opioid receptor,Kappa-type opioid receptor,KOR 1,KOR,KOR-1,Opiate receptor kappa 1,Opiate receptor,kappa 1,Opioid receptor,kappa 1,OPRK 1,OPRK,OPRK,OPRK1,Oprk2,R21
Swissprot P41145
Source Rabbit
Reactivity Mouse,Rat
Immunogen A synthetic peptide of human OPRK1
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

 

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