OPTN Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-15313

Overview

Synonyms 14.7K interacting protein,Ag9 C5,ALS12,E3 14.7K interacting protein,E3-14.7K-interacting protein,FIP 2,FIP-2,FIP2,Glaucoma 1 open angle E (adult onset),Glaucoma 1 open angle E,GLC1E,HIP 7,HIP-7,HIP7,Huntingtin interacting protein 7,Huntingtin interacting protein HYPL,Huntingtin interacting protein L,Huntingtin yeast partner L,Huntingtin-interacting protein 7,Huntingtin-interacting protein L,HYPL,Injury inducible protein I 55,NEMO related protein,NEMO-related protein,NRP,Optic neuropathy inducing protein,Optic neuropathy-inducing protein,Optineurin,OPTN,OPTN,TFIIIA IntP,TFIIIA-IntP,Transcription factor IIIA interacting protein,Transcription factor IIIA-interacting protein,Tumor necrosis factor alpha inducible cellular protein containing leucine zipper domains
Swissprot Q96CV9
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human OPTN
Application IHC,ELISA
Recommended dilution IHC 1:25-1:100
Concentration 0.3mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins.

 

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