PI 3 Kinase C2 gamma Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-34240

Overview

Synonyms P3C2G,Phosphatidylinositol 4 phosphate 3 kinase C2 domain containing gamma polypeptide,Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma,Phosphoinositide 3 Kinase C2 gamma,Phosphoinositide 3-Kinase-C2-gamma,PI3K C2gamma,PI3K-C2-gamma,PIK3C2G,PtdIns 3 kinase C2 gamma,PtdIns-3-kinase C2 subunit gamma
Swissprot O75747
Source Rabbit
Reactivity Human
Immunogen Synthesized peptide derived from the N-terminal region of human PI 3-Kinase C2γ.
Application WB,ELISA
Recommended dilution WB 1:500-1:2000, ELISA 1:10000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. PIK3C2G (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma) is a Protein Coding gene. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and mTOR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3C2B.

 

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