PIM2 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-10916

Overview

Synonyms OTTHUMP00000025825,Pim 2 oncogene,Pim 2h,Pim-2h,PIM2,PIM2 Oncogene,PIM2,Pim2h,Proto Oncogene PIM2,Proto-oncogene Pim-2 (serine threonine kinase),Serine/threonine kinase PIM2,Serine/threonine-protein kinase Pim-2
Swissprot Q9P1W9
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant protein of human PIM2
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.3mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival. Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity.

 

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