PKLR Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64127

Overview

Synonyms EC 2.7.1.40,KPYR,L-PK,Pk-1,PK1 ,PKL ,Pklg,Pklr,PKR,PKRL,Pyruvate kinase 1,Pyruvate kinase isozymes R/L,Pyruvate kinase liver and blood cell,Pyruvate kinase liver and RBC,Pyruvate kinase liver and red blood cell,Pyruvate kinase liver type,Pyruvate kinase type L,Pyruvate kinase, red cell type,R type/L type pyruvate kinase,R-PK,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase,RPK
Swissprot P30613
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human PKLR
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.

 

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