Overview
Synonyms | HC8,Macropain subunit C8,MGC12306,MGC32631,Multicatalytic endopeptidase complex subunit C8,Proteasome (prosome macropain) subunit alpha type 3,Proteasome alpha 3 subunit,Proteasome component C8,Proteasome subunit alpha type 3,Proteasome subunit alpha type-3,Proteasome subunit C8,PSA3,PSC8,psmA3 |
Swissprot | P25788 |
Source | Rabbit |
Reactivity | Human,Mouse |
Immunogen | Recombinant protein of human PSMA3 |
Application | WB,IF |
Recommended dilution | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Concentration | 1mg/ml |
Clonality | Polyclonal |
Properties
Cellular localization | |
Tissue specificity | |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Background | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. |