Overview
| Synonyms | HC8,Macropain subunit C8,MGC12306,MGC32631,Multicatalytic endopeptidase complex subunit C8,Proteasome (prosome macropain) subunit alpha type 3,Proteasome alpha 3 subunit,Proteasome component C8,Proteasome subunit alpha type 3,Proteasome subunit alpha type-3,Proteasome subunit C8,PSA3,PSC8,psmA3 |
| Swissprot | P25788 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human PSMA3 |
| Application | WB,IF |
| Recommended dilution | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Concentration | 1mg/ml |
| Clonality | Polyclonal |
Properties
| Cellular localization | |
| Tissue specificity | |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Background | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. |
