PSMD3 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-60783

Overview

Synonyms 26S proteasome non ATPase regulatory subunit 3,26S proteasome non-ATPase regulatory subunit 3,26S proteasome regulatory subunit RPN3,26S proteasome regulatory subunit S3,OTTHUMP00000164347,P58,Proteasome (prosome,macropain) 26S subunit non ATPase 3,Proteasome subunit p58,PSMD3,PSMD3,RPN3,S3,Tissue specific transplantation antigen 2,TSTA2
Swissprot O43242
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen A synthetic peptide of human PSMD3
Application WB,IHC
Recommended dilution WB 1:500 - 1:2000 IHC 1:50 - 1:200
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count.

 

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