PSMD8 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-14321

Overview

Synonyms 26S proteasome non ATPase regulatory subunit 8,26S proteasome non-ATPase regulatory subunit 8,26S proteasome regulatory subunit p31,26S proteasome regulatory subunit RPN12,26S proteasome regulatory subunit S14,AAV38494 ,HIP6,HYPF,MGC1660,Nin1p,P31,Proteasome (prosome macropain) 26S subunit non ATPase 8,PSMD8,PSMD8,Rpn12,S14
Swissprot P48556
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant protein of human PSMD8
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.2mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.

 

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