PTPN22 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-15316

Overview

Synonyms Hematopoietic cell protein tyrosine phosphatase 70Z PEP,Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP,Lymphoid phosphatase,Lymphoid specific protein tyrosine phosphatase,lymphoid-specific,inducible human protein tyrosine phosphatase,Lyp 1,Lyp 2,LyP,Lyp1,Lyp2,LyPTP,OTTHUMP00000013720,OTTHUMP00000013721,OTTHUMP00000233450,OTTHUMP00000233451,PEP,PEST-domain phosphatase,Protein tyrosine phosphatase non receptor type 22 (lymphoid),Protein tyrosine phosphatase non receptor type 22,Protein tyrosine phosphatase non receptor type 8,Protein tyrosine phosphatase non receptor type 8,formerly,PTN22,PTPN 22,PTPN 8,Ptpn22,PTPN8,PTPN8,formerly,Tyrosine-protein phosphatase non-receptor type 22
Swissprot Q9Y2R2
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant protein of human PTPN22
Application WB,IHC,ELISA
Recommended dilution WB 1:200-1:1000, IHC 1:25-1:100
Concentration 0.3mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

 

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