RASGEF1A Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-15331

Overview

Synonyms CG4853 gene product,Ras-GEF domain-containing family member 1A,RasGEF domain family,member 1A,rasgef1a,RGF1A
Swissprot Q8N9B8
Source Rabbit
Reactivity Human
Immunogen Recombinant protein of human RASGEF1A
Application IHC,ELISA
Recommended dilution IHC 1:10-1:50
Concentration 0.2mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background RASGEF1A (RasGEF domain family, member 1A) is a 481 amino acid guanine-nucleotide exchange factor (GEF) for H-Ras, K-Ras, and N-Ras. RASGEF1A may also play a role in cell migration. RASFEG1A is highly expressed in spinal chord and brain and contains one N-terminal Ras-GEF domain and one Ras-GEF domain. The gene that encodes RASGEF1A maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. 

 

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