RBFOX3 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-70331

Overview

Synonyms FLJ56884,FLJ58356,Fox-1 homolog C,fox1 homolog C,Fox3,FOX3NeuN,hexaribonucleotide binding protein 3,HRNBP3,NEUN,neuronal nuclei,Rbfox3,RFOX3,RNA binding protein fox-1 homolog 3,RNA binding protein,fox 1 homolog (C. elegans) 3
Swissprot A6NFN3,Q8BIF2
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein corresponding to Mouse NEUN
Application WB
Recommended dilution WB 1:1000
Concentration 1 mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
Background Immunoprecipitation and mass spectrometry of the two major NeuN species at 45–50 kDa identified both as the RNA binding protein Rbfox3 (a member of the Fox family of alternative splicing factors), confirming and extending the identification of the 45 kDa band as Rbfox3. Mapping of the anti-NeuN reactive epitopes in both R3hdm2 and Rbfox3 reveals a common proline- and glutamine-rich domain that lies at the N-terminus of the Rbfox3 protein. Nuclear Rbfox3 isoforms can also enhance the inclusion of cryptic exons in the Rbfox2 mRNA, resulting in nonsense-mediated decay of the message, thereby contributing to the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism.

 

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