RNF20 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-15354

Overview

Synonyms BRE1 A,BRE1,BRE1 E3 ubiquitin ligase homolog,BRE1-A,BRE1A,BRE1A,E3 ubiquitin-protein ligase BRE1A,hBRE1,Homolog of S. cerevisiae BRE1,RING finger protein 20,Ring finger protein 20 E3 ubiquitin protein ligase,Rnf20
Swissprot Q5VTR2
Source Rabbit
Reactivity Human,Mouse
Immunogen Recombinant protein of human RNF20
Application WB,IHC,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:20-1:100
Concentration 0.4mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor.

 

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