ROCK1 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-70124

Overview

Synonyms coiled-coil-containing protein kinase 1,coiled-coil-containing protein kinase I,MGC131603,MGC43611,p160 Rhoassociated coiled coil-forming protein kinase,p160 ROCK-1,p160 ROCK1,p160ROCK,PRO0435,Renal carcinoma antigen NY REN 35,Renal carcinoma antigen NY-REN-35,Rho associated coiled coil containing protein kinase 1,Rho associated protein kinase 1,Rho kinase,Rho-alpha kinase,Rho-associated,Rho-associated protein kinase 1,ROCK I,ROCK-I,ROCK1,ROCK1,Rok,rokalpha
Swissprot P70335,Q63644
Source Rabbit
Reactivity Mouse,Rat
Immunogen KLH conjugated Synthetic peptide corresponding to Mouse Rock1
Application IHC
Recommended dilution IHC 1:100-1:400
Concentration 300 μg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
Background This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

 

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