RPSA Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-10457

Overview

Synonyms 34/67 kDa laminin receptor,37 kDa laminin receptor precursor,37/67 kDa laminin receptor,37LRP,40S ribosomal protein SA,67 kDa laminin receptor,67LR,Colon carcinoma laminin binding protein,Colon carcinoma laminin-binding protein,LAMBR,Laminin receptor 1,Laminin-binding protein precursor p40,LAMR 1,LamR,LAMR1,LBP,LBP/p40,LRP,LRP/LR,Multidrug resistance associated protein MGr1 Ag,Multidrug resistance associated protein MGr1Ag,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,p40,Ribosomal Protein SA,rpsA,RSSA,SA
Swissprot P08865
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human RPSA
Application WB,ELISA
Recommended dilution WB 1:500-1:2000
Concentration 0.3mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene

 

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