RTKN Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64574

Overview

Synonyms Rhotekin,Rtkn,RTKN,RTKN1
Swissprot Q9BST9
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human RTKN
Application WB,IF
Recommended dilution WB 1:500 - 1:2000 IF 1:50 - 1:200
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

 

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