SCARB2 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64311

Overview

Synonyms 85 kDa lysosomal membrane sialoglycoprotein,85 kDa lysosomal sialoglycoprotein scavenger receptor class B member 2,AMRF,CD36,CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II),CD36 antigen,CD36 antigen-like 2,CD36L2,EPM4,HLGP85,LGP85,LIMP 2,LIMP II,LIMP2,LIMPII,Lysosomal integral membrane protein II,Lysosome membrane protein 2,Lysosome membrane protein II,OTTHUMP00000160590,OTTHUMP00000219176,Scarb2,Scavenger receptor class B member 2,Scavenger receptor class B, member 2,SCRB2,SR BII,SRBII
Swissprot Q14108
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human SCARB2
Application WB
Recommended dilution WB 1:1000 - 1:3000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

 

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