SCN1A Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-16049

Overview

Synonyms brain sodium channel type I,EIEE6,FEB3,FEB3A,FHM3,GEFS+2,GEFSP2,HBSC I,HBSCI,NAC1,Nav 1.1,RBI,SCN1,Scn1a,SCN1A,SMEI,Sodium channel protein brain I alpha subunit,Sodium channel protein brain I subunit alpha,Sodium channel protein type 1 subunit alpha,Sodium channel protein type I subunit alpha,Sodium channel voltage gated type 1 alpha subunit,Sodium channel voltage gated type I alpha polypeptide,Voltage-gated sodium channel subunit alpha Nav1.1
Swissprot P35498
Source Rabbit
Reactivity Human,Rat
Immunogen Synthetic peptide of human SCN1A/2A/3A/4A/5A/8A/9A/10A/11A/13A
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.5mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.

 

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