SERPINB5 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-31974

Overview

Synonyms Maspin,Ovalbumin,Peptidase inhibitor 5,PI-5,PI5,protease inhibitor 5 (maspin),Protease inhibitor 5,Serine (or cysteine) peptidase inhibitor,clade B,member 5,serine (or cysteine) proteinase inhibitor,clade B (ovalbumin),member 5,Serpin B5,serpin family B member 5,Serpin peptidase inhibitor,Serpin peptidase inhibitor,clade B (ovalbumin),member 5,Serpinb5,SPB5,Spi5,Spi7
Swissprot P36952
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the Internal region of human Maspin
Application WB,IHC-p,IF,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background Maspin (mammary serine protease inhibitor) also known as serpin B5 is a protein that in humans is encoded by the SERPINB5 gene.[1] This protein belongs to the serpin (serine protease inhibitor) superfamily.[1] SERPINB5 also functions as a tumor suppressor gene in epithelial cells. The expressed protein suppresses the ability of cancer cells to invade and metastasize other tissues. The protein also functions as an angiogenesis inhibitor.It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

 

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