SERPINB6 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-15385

Overview

Synonyms CAP,Cytoplasmic antiproteinase,Peptidase inhibitor 6,PI-6,PI6,Placental thrombin inhibitor,Protease inhibitor 6 (placental thrombin inhibitor),PTI,Serpin B6,SERPINB6,SPB6
Swissprot P35237
Source Rabbit
Reactivity Human
Immunogen Recombinant protein of human SERPINB6
Application IHC,ELISA
Recommended dilution IHC 1:25-1:100
Concentration 0.6mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene.

 

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