SPTA1 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-63689

Overview

Synonyms Alpha I spectrin,EL 2,EL2,Elliptocytosis 2,Elliptocytosis2,Erythrocyte alpha spectrin,erythrocyte,Erythroid alpha spectrin,Erythroid alpha-spectrin,Erythroid spectrin alpha,HPP,HS3,Spectrin alpha chain,Spectrin alpha chain erythrocyte,Spectrin alpha erythrocytic 1,SPH3,SPTA 1,SPTA,SPTA1,SPTA1
Swissprot P02549
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human SPTA1
Application WB
Recommended dilution WB 1:500 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.

 

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