SUPT16H Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-32948

Overview

Synonyms CDC68,Chromatin specific transcription elongation factor 140 kDa subunit,Chromatin-specific transcription elongation factor 140 kDa subunit,Facilitates chromatin transcription complex subunit SPT16,FACT 140 kDa subunit,FACT,FACT complex subunit SPT16,FACTp140,FLJ10857,FLJ14010,hSPT16,SP16H,Suppressor of Ty 16 homolog,Supt16h
Swissprot Q9Y5B9
Source Rabbit
Reactivity Human,Mouse
Immunogen Synthesized peptide derived from the C-terminal region of human SPT16
Application WB,IHC-p,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Background Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit.SUPT16H (SPT16 Homolog, Facilitates Chromatin Remodeling Subunit) is a Protein Coding gene. Diseases associated with SUPT16H include Ceroid Lipofuscinosis, Neuronal, 2 and Leukoencephalopathy With Vanishing White Matter. Among its related pathways are HIV Life Cycle and Regulation of TP53 Activity. GO annotations related to this gene include poly(A) RNA binding.

 

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