TBC1D22A Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-17050

Overview

Synonyms C22orf4,chromosome 22 open reading frame 4,HSC79E021,OTTHUMP00000028753,putative GTPase activator,TBC1 domain family member 22A,TBC1D22A
Swissprot Q8WUA7
Source Rabbit
Reactivity Human,Mouse
Immunogen Fusion protein of human TBC1D22A
Application IHC,ELISA
Recommended dilution IHC 1:25-100, ELISA 1:2000-5000
Concentration 0.4mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background TBC1D22A (TBC1 domain family, member 22A), also known as C22orf4, is a 517 amino acid protein that contains one Rab-GAP TBC domain and is thought to function as a GTPase-activating protein for Rab family members. Multiple isoforms of TBC1D22A exist due to alternative splicing events. The gene encoding TBC1D22A maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.

 

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