TLR5 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-14647

Overview

Synonyms FLJ10052,MGC126430,MGC126431,SLEB1,TIL 3,TIL3,TLR 5,Tlr5,TLR5,Toll like receptor 5,Toll like receptor 5 precursor,Toll-like receptor 5,Toll/interleukin 1 receptor like protein 3,Toll/interleukin-1 receptor-like protein 3
Swissprot O60602
Source Rabbit
Reactivity Human
Immunogen Recombinant protein of human TLR5
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.3mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.

 

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