TNFRSF13C Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-16646

Overview

Synonyms B cell activating factor receptor,B-cell-activating factor receptor,BAFF R,BAFF receptor,BAFF-R,BAFFR,BLyS receptor 3,BlySR3,BR 3,BR3,BROMIX,CD 268,CD268,CD268 antigen,CVID4,MGC138235,OTTHUMP00000028746,Prolixin,TNFRSF 13C,Tnfrsf13c,TR13C,Tumor necrosis factor receptor subunit member 13C,Tumor necrosis factor receptor superfamily member 13C
Swissprot Q96RJ3
Source Rabbit
Reactivity Human,Mouse
Immunogen Synthetic peptide of human TNFRSF13C
Application IHC,ELISA
Recommended dilution IHC 1:50-1:200
Concentration 0.7mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.

 

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