TRAF2 Polyclonal Antibody

Rs. 16,500.00
SKU E-AB-33137

Overview

Synonyms E3 ubiquitin-protein ligase TRAF2,MGC:45012,OTTHUMP00000022625,OTTHUMP00000064745,TNF receptor associated factor 2,TNF receptor-associated factor 2,TNF receptor-associated protein,TRAF 2,TRAF2,TRAF2,TRAP 3,TRAP,TRAP3,Tumor necrosis factor type 2 receptor associated protein 3,Tumor necrosis factor type 2 receptor-associated protein 3
Swissprot Q12933
Source Rabbit
Reactivity Human
Immunogen Synthesized peptide derived from the Internal region of human TRAF2.
Application WB,IHC-p,ELISA
Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Concentration 1mg/mL
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain.

 

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