ZBTB33 Polyclonal Antibody

Rs. 21,832.00
SKU E-AB-64367

Overview

Synonyms Kaiso,Kaiso protein,Kaiso transcription factor,KAISO,Transcriptional regulator Kaiso,ZBTB 33,Zbtb33,Zinc finger and BTB domain containing 33,Zinc finger and BTB domain-containing protein 33,Zinc finger transcription factor Kaiso,ZNF 348,ZNF Kaiso,ZNF348
Swissprot Q86T24
Source Rabbit
Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human ZBTB33
Application WB
Recommended dilution WB 1:1000 - 1:2000
Concentration 1mg/ml
Clonality Polyclonal

Properties

Cellular localization  
Tissue specificity  
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

 

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