Overview
Synonyms | hREX-1,Reduced Expression 1 Protein,Reduced expression protein 1,Rex-1,REX1,REX1 transcription factor,Zfp-42,Zfp42,ZFP42 zinc finger protein,ZFP42,Zinc finger protein 42 homolog,Zinc finger protein 754,ZNF754 |
Swissprot | Q96MM3 |
Source | Rabbit |
Reactivity | Human |
Immunogen | Synthetic peptide of human ZFP42 |
Application | WB,ELISA |
Recommended dilution | WB 1:200-1:1000 |
Concentration | 0.2mg/mL |
Clonality | Polyclonal |
Properties
Cellular localization | |
Tissue specificity | |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
Background | Rex-1 (for reduced expression), also designated zinc finger protein 42 (ZFP42), is an acidic zinc finger protein. Rex-1 contains four repeats of the zinc finger nucleic acid-binding motif and a potential acidic activator domain, suggesting that it is a regulatory protein. Rex-1 localizes to the nucleus and is highly expressed in embryonic stem (ES) and undifferentiated murine F9 teratocarcinoma cells. At the transcriptional level, expression of Rex-1 is reduced when F9 cells are induced to differentiate by the addition of retinoic acid (RA), and Rex-1 repression is enhanced by E1A. The Oct-3/4 transcription factor can either activate or repress the Rex-1 promoter, depending on the cellular environment, while Oct-6 can lower the expression of Rex-1. |