Overview
| Synonyms | hREX-1,Reduced Expression 1 Protein,Reduced expression protein 1,Rex-1,REX1,REX1 transcription factor,Zfp-42,Zfp42,ZFP42 zinc finger protein,ZFP42,Zinc finger protein 42 homolog,Zinc finger protein 754,ZNF754 |
| Swissprot | Q96MM3 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human ZFP42 |
| Application | WB,ELISA |
| Recommended dilution | WB 1:200-1:1000 |
| Concentration | 0.2mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | |
| Tissue specificity | |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Rex-1 (for reduced expression), also designated zinc finger protein 42 (ZFP42), is an acidic zinc finger protein. Rex-1 contains four repeats of the zinc finger nucleic acid-binding motif and a potential acidic activator domain, suggesting that it is a regulatory protein. Rex-1 localizes to the nucleus and is highly expressed in embryonic stem (ES) and undifferentiated murine F9 teratocarcinoma cells. At the transcriptional level, expression of Rex-1 is reduced when F9 cells are induced to differentiate by the addition of retinoic acid (RA), and Rex-1 repression is enhanced by E1A. The Oct-3/4 transcription factor can either activate or repress the Rex-1 promoter, depending on the cellular environment, while Oct-6 can lower the expression of Rex-1. |
